Researchers around the world are working to find better ways to prevent, detect, and treat breast cancer, and to improve the quality of life of patients and survivors.
Some of the many active areas of research include:
- Breast cancer causes
- Causes and treatment of metastatic breast cancer
- Reducing breast cancer risk
- Managing ductal carcinoma in situ (DCIS)
- New lab tests for breast cancer
- New imaging tests for breast cancer
- Breast cancer treatment
- Supportive care
Breast cancer causes
Studies continue to uncover lifestyle factors and habits, as well as inherited genes, that affect breast cancer risk. Here are a few examples:
- Several studies are looking at the effect of exercise, weight gain or loss, and diet on risk.
- Studies on the best use of genetic testing for breast cancer mutations continue at a rapid pace.
- Scientists are exploring how common gene variations (small changes in genes that are not as significant as mutations) may affect breast cancer risk. Gene variants typically have only a modest effect on risk, but when taken together they could possibly have a large impact.
- Possible environmental causes of breast cancer have also received more attention in recent years. While much of the science on this topic is still in its earliest stages, this is an area of active research.
Reducing breast cancer risk
Researchers continue to look for medicines that might help lower breast cancer risk, especially women who are at high risk.
- Hormone therapy drugs are typically used to help treat breast cancer, but some might also help prevent it. Tamoxifen and raloxifene have been used for many years to prevent breast cancer. More recent studies with another class of drugs called aromatase inhibitors (exemestane and anastrozole) have shown that these drugs are also very effective in preventing breast cancer
- Other clinical trials are looking at non-hormonal drugs for breast cancer reduction. Drugs of interest include drugs for osteoporosis and bone metastases, COX-2 inhibitors, non-steroidal anti-inflammatory drugs, and statins (used to lower cholesterol).
When breast cancer spreads, it often goes to the bones. Some drugs that help treat the spread of cancer to the bones (such as bisphosphonates and denosumab), might also help reduce the chances of the cancer coming back. Studies done so far seem to suggest that postmenopausal women may benefit the most from giving these bone-modifying drugs after breast surgery, but more studies are needed to say for sure.
This type of research takes many years. It might be some time before meaningful results on any of these compounds are available.
In ductal carcinoma in situ (DCIS), the abnormal cells are in the milk duct and have not grown outside the duct.. In some women, DCIS turns into invasive breast cancer, or sometimes an area of DCIS contains invasive cancer. In other women, though, the cells just stay within the ducts and never invade deeper or spread to lymph nodes or other organs. The uncertainty about how DCIS will behave can make it hard to choose the best treatments. Researchers are looking for ways to help with these challenges.
Researchers are studying ways to use computers and statistical methods to estimate the odds that a woman’s DCIS will become invasive. Decision aids are another approach. They ask a woman with DCIS questions that help her decide which factors (such as survival, preventing recurrence, and side effects) she considers most important in choosing a treatment.
New lab tests
Tests for circulating tumor cells (CTCs)
Researchers have found that in many women with breast cancer, cells may break away from the tumor and enter the blood. These circulating tumor cells (CTCs) can be detected with sensitive lab tests. Although these tests can help predict which patients may have breast cancer that has spread beyond the breast (metastatic disease), it isn’t clear if the use of these tests can tell whether the cancer will come back after treatment (recur) or help patients live longer. Some studies are looking at if these CTCs can be removed and then tested in the lab to determine which specific anticancer drugs will work on the tumor.
New imaging tests
Newer imaging methods are now being studied for evaluating breast changes that may be cancer.
Scintimammography (molecular breast imaging)
In this test, a slightly radioactive drug called a tracer is injected into a vein. The tracer attaches to breast cancer cells and is detected by a special camera.
This technique is still being studied to see if it will be useful in finding breast cancers. Some doctors believe it may be helpful in looking at suspicious areas found by regular mammograms, but its exact role is still unclear. Current research is aimed at improving the technology and evaluating its use in specific situations such as in the dense breasts of younger women.
Breast cancer treatment
It is known that chemotherapy can be helpful for many breast cancer patients. But predicting who will benefit the most or the least is still being studied. Sometimes there are significant side effects (long- and short-term) from chemotherapy, so having tests that can determine who really needs chemo would be useful. Many studies are being done to evaluate different tests that can more accurately tell which patients would benefit from chemo and which patients could avoid it.
Breast-conserving surgery (lumpectomy or partial mastectomy) can often be used for early-stage breast cancers. But for some women, it can result in breasts of different sizes and/or shapes. For larger tumors, it might not even be possible, and a mastectomy might be needed instead. Some doctors are addressing this problem by combining cancer surgery and plastic surgery techniques, known as oncoplastic surgery. This typically involves reshaping the breast at the time of the initial surgery, such as doing a partial breast reconstruction after breast-conserving surgery or a full reconstruction after mastectomy. Oncoplastic surgery may mean operating on the other breast as well to make the breasts more alike.
Triple-negative breast cancer
Since triple-negative breast cancers cannot be treated with hormone therapy or targeted therapy such as HER2 drugs, the treatment options are limited to chemotherapy. Other potential targets for new breast cancer drugs have been identified in recent years. Drugs based on these targets, such as kinase inhibitors and immunotherapy, are now being studied to treat triple-negative breast cancers, either by themselves, in combination, or with chemotherapy.
Targeted therapy drugs
Targeted therapies are a group of drugs that specifically target gene changes in cancer cells that help the cells grow or spread. New targeted therapies are being studied for use against breast cancer, including PARP inhibitors. These drugs are most likely to be helpful against cancers caused by BRCA gene mutations, and have shown some promise in treating some types of breast cancers. Olaparib (Lynparza) is now being used to treat women with BRCA mutations who have metastatic, HER2-negative breast cancer and who have already gotten chemotherapy. Other PARP inhibitors are also being studied.
There are trials looking at different medicines to try and improve memory and brain symptoms after chemotherapy. Other studies are evaluating if certain cardiac drugs, known as beta-blockers, can prevent the heart damage sometimes caused by the common breast cancer chemotherapy drugs, doxorubicin and epirubicin.
Thinking about taking part in a clinical trial
Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the art cancer treatment. In some cases, they may be the only way to get access to newer treatments. They are also the best way for doctors to learn better methods to treat cancer. Still, they are not right for everyone.
If you would like to learn more about clinical trials that might be right for you, start by asking your doctor if your clinic or hospital conducts clinical trials, or see Clinical Trials to learn more.
Breast Cancer: Current Research is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Breast Cancer: Current Research aims to publish articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is to develop a new focus and new perspectives for all who are concerned with breast cancer. Breast Cancer: Current Research presents the open access articles in all areas of biology and medicine relevant to breast cancer, including invasive ductual carcinoma, with special emphasis on the inflammatory breast cancer, Breast cancer cure, and advances in Breast cancer treatment. In addition to basic research, the journal publishes mastectomy, alternative treatments for breast cancer, Fibrocystic breast, mammography, etc.
This scholarly publishing Editorial Manager System for quality in the review process. Editorial Manager System is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of Breast Cancer: Current Research or outside experts; at least two independent reviewer’s approval followed by the editor is required for the acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.
Smoking in Breast Cancer
Smoking causes a number of diseases and is linked to a higher risk of breast cancer in younger, premenopausal women. Smoking also can increase complications from breast cancer treatment such as damage to the lungs from radiation therapy and difficulty healing after surgery and breast reconstruction.
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Breast Cancer Radiotherapy
Radiotherapy is a treatment for cancer that uses carefully measured and controlled high energy x-rays. Radiation to the breast is often given after breast-conserving surgery to help lower the chance that the cancer will come back in the breast or nearby lymph nodes. External beam radiation is the most common type of radiation therapy for women with breast cancer.
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Breast Cancer Research
Breast cancer research into the causes, prevention, and treatment of breast cancer is being done in many medical centers throughout the world. Studies continue to find lifestyle factors and habits that alter breast cancer risk. Some studies are looking at the effect of exercise, weight gain or loss, and diet on breast cancer risk. We are also learning more about how genes influence breast cancer. This should happen more quickly now that the human genome has been mapped out.
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Breast Cancer Therapeutic & Market Analysis
Breast cancer therapeutic & market analysis assesses marketed and investigational products and combination regimens for the global breast cancer therapeutics market. Segmentation by drug class is provided, along with supporting information, such as clinical trial timelines and results, historical and projected launch timelines, and epidemiology. Marketed and pipeline products are broadly segmented into hormonal therapy, targeted therapy, chemotherapy, and other therapies of current global interest.
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Invasive Ductal Carcinoma
Intrusive ductal carcinoma (IDC), once in a while called invading ductal carcinoma, is the most well-known kind of breast tumor. Around 80% of all breast growths are intrusive ductal carcinomas. Intrusive implies that the growth has "attacked" or spread to the encompassing breast tissues.
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Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is an uncommon and extremely forceful infection in which cancer cells block lymph vessels in the skin of the breast. This sort of breast disease is called "provocative" on the grounds that the bosom frequently looks swollen and red, or "excited." Inflammatory breast cancer usually starts with the reddening and swelling of the breast instead of a distinct lump. IBC tends to grow and spread quickly with the symptoms of breast warmth, breast may become harder, thickening of the skin of the breast, redness involving more than one third of the breast.
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Advances in Breast Cancer Treatment
Studies keep on uncovering way of life components and propensities that change bosom malignancy hazard. Progressing studies are taking a gander at the impact of activity, weight pick up or misfortune, and eating routine on bosom tumor hazard. New Advances in Breast cancer treatment are: Chemoprevention, Settling on choices about DCIS, New lab tests, Circling tumor cells, More up to date imaging tests,Oncoplastic surgery, New chemotherapy drugs, Bisphosphonates, Denosumab, Mastectomy.
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Making Strides in Breast Cancer
Each three-to five-mile Making Strides Against Breast Cancer walk is a capable and raising chance to unite as a group to respect breast growth survivors, bring issues to light about steps we can take to diminish the danger of getting bosom tumor, and raise cash to help the American Cancer Society lead the battle against this malady with earth shattering bosom malignancy research, data and bolster all day, every day, and access to mammograms for ladies who need them.
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Terminal Breast Cancer
Breast cancer is a huge opponent in the world of women, but terminal cancer is something that just boggles the mind and heart of any man or woman.
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Hereditary Breast Cancer
Hereditary Breast and Ovarian Cancer (HBOC) should be considered when there are multiple cases of breast cancer on the same side of the family. There is breast cancer in multiple generations on the same side of the family, such as having both a grandmother and an aunt on your father’s side diagnosed. A woman is diagnosed with a second breast cancer in the same or the other breast or has both breast and ovarian cancers.
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Mastectomy is surgery to remove all breast tissue from a breast as a way to treat or prevent breast cancer. For those with early-stage breast cancer, mastectomy may be one treatment option. Breast-conserving surgery (lumpectomy), in which only the tumor is removed from the breast, may be another option.
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Gynecology & Obstetrics, Cancer Science & Therapy, Cancer Diagnosis, Archives in Cancer Research, Clinical Breast Cancer, Breast diseases, Cancer detection and prevention, Research In Cancer and Tumor
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